The Chemistry of Vanilla – Three Ways Vanillin Is Made

Vanilla is one of the most common and popular flavours in food. Are there ice cream shops that do not sell a vanilla ice cream?

There are several ways to make food taste like vanilla. The most straightforward one is to use the original source: natural vanilla which is a pod that grows on the vanilla plant. Instead of using the pod, you could use an extract of it as well. A lot of commercial bakery products though (especially in the US) use artificial vanilla, which technically is vanillin.

We’ve discussed the difference between vanilla & vanillin before. But how is vanillin itself made? If it doesn’t grow on a plant, how can we make it?

Vanillin molecule

Pure vanilla originates from vanilla beans and is a complex mixture of flavour molecules. However, there is one molecule that is mostly associated with vanilla: vanillin. It has a huge contribution to natural vanilla and for many of you, vanillin might actually be what you think of when you think of vanilla.

Vanillin naturally occurs in vanilla beans, but, it can also be made without the intervention of a single vanilla bean. Vanillin is a molecule, shown below. It’s molecular formula is C8H8O3¬†and one of its chemical names is: 4-hydroxy-3-methoxybenzaldehyde. Pure vanillin is generally sold as a (crystalline) powder and is white (maybe slightly yellowish). Vanillin can be bought with a wide variety of suppliers which may use several different routes to make vanillin.

There are roughly two ways to make vanillin. The first is to find a more common molecule that already exists in nature and transform it into vanilla using various chemical reactions. The other method uses yeasts to make vanillin molecules from pretty different molecules.


1. Making vanillin from eugenol

Vanillin is an expensive ingredient, so it stimulates the industry to look for cheaper ways to make the product. One of these ways is to take molecules that occur in natur in higher quantities (thus are cheaper) and convert those into vanillin. Eugenol is such a molecule.

Eugenol can be extracted from spices such as cinnamon, nutmeg and cloves. Its structure is very similar to that of vanillin as you can see in the structure shown below (source). The only difference sits in the top branch where it lacks the oxygen (O) group and instead has a longer carbon tail.


When converting eugenol to vanillin two chemical process steps have to take place:

  1. Isomerization of the eugenol: in other words, the double bond of the eugenol will move from the top to one position lower.
  2. Oxidation of the isoeugenol, thus adding that oxygen group.


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Look into the sources at the bottom of this post to find more detailed articles (and patents), describing the chemical steps and processes in more detail.

2. Lignin (wood pulp) to make vanillin

Despite eugenol being a slightly cheaper way to make vanillin, development has continued and nowadays most of the vanillin is not made from eugenol anymore, instead it is made from lignin and guaiacol. The image below shows an illustration of how lignin could look like (source). If you look closely you can again recognize the structure of the vanillin molecule.

lingin structure source wikipedia

There are several ways to make vanillin from lignin. The easiest processes however tend to use a lot of harsh chemical solvents or very strong acids and bases which makes them very environmentally unfriendly. Therefore, a lot of research is done into better ways of making vanillin from both lignin as well as guaiacol. Big steps have been made and are being made

3. Using yeast to make vanillin (natural)

Developments do continue within the world of vanillin production. In recent years the wish for natural vanillin has increased under consumers. However, most harsh chemical processes described above do not fit that definition. A comming route that various companies look into for making natural vanillin though is the use of micro organisms. Certain yeasts, fungi and bacteria can be used to make vanillin from other (naturally occuring) molecules.

Several processes are already used to make vanillin with the use of micro organisms. That said, it is not easy to get these processes to work efficiently. One of the most interesting factors at play I found was the fact that vanillin is actually toxic to several micro organisms. So the concentrations the micro organisms make themselves have to be kept low to prevent them from dying.

If you’re interested in more chemical details I would suggest reading this article which has a very extensive analysis of the various routes being investigated.


There are several patents available describing in more detail how to make vanillin from eugenol, here is one example.

In the 1970’s a teacher designed a nice classroom experiment allowing students to make vanillin from eugenol themselves.

A very complete research article about the history of vanillin synthesis.

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  1. I have an allergy to both Vanillin and Eugenol and recently discovered that asparagus contains both of these compounds.
    I am wondering what other vegetable or maybe fruits contain these chemicals.
    They make me very poorly.

    • Hi Margaret,

      I must admit that I do not have a full list of fruits and vegetables that contain eugenol. Generally speaking, you can expect to find eugenol in a lot of spices such as cinnamon, cloves and bay leaf. While doing some research I found this introductory article that seems to cover some of the groups you’re referring to. I do not have enough expertise on allergies to vouch for its correctness, but it might provide a starting point in your further research. Good luck!

  2. I was toiling around finding a cheaper method to make synthetic vanillin and fortunately have found one.

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